{"metadata":{"accession":"PF19398","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046016","hierarchy":null,"name":{"name":"Lantibiotic duramycin B-like","short":"DurB-like"},"description":[{"text":"<p>This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001577) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide). It includes lantibiotic duramycin, duramycin B and cinnamycin. Duramycin B is a potent inhibitor of human phospholipase A2 [[cite:PUB00151902]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151902":{"PMID":2125590,"ISBN":null,"volume":"43","issue":"11","year":1990,"title":"Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.","URL":null,"raw_pages":"1403-12","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J Antibiot (Tokyo)","authors":["Fredenhagen A","Fendrich G","Marki F","Marki W","Gruner J","Raschdorf F","Peter HH."],"DOI_URL":"https://doi.org/10.7164/antibiotics.43.1403"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":63,"pathways":0,"proteins":63,"proteomes":52,"sets":0,"structural_models":{"alphafold":36},"structures":1,"taxa":119},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":19},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6c0h","name":"Lysinoalanine synthase, DurN, from duramycin biosynthesis bound to 1-Dha6Ala"}}}