This entry represents a presumed domain that is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 294 and 327 amino acids in length. Many proteins in this family are annotated at Topoisomerase II, but the source of this annotation is unclear.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":2433,"pathways":0,"proteins":2423,"proteomes":2409,"sets":0,"structural_models":{"alphafold":1364},"structures":0,"taxa":2856},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":35,"alignment:full":1219},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}