This family represents a domain of unknown function located between the Transcription factor IIIC subunit delta N-term ([pfam:PF12657]) and the Putative zinc-finger of transcription factor IIIC complex ([pfam:PF12660]) within the transcription Factor IIIC 90 kDa subunit (TFIIIC-delta/TFIIIC90, also known as general transcription factor 3C polypeptide 4). TFIIIC is a multisubunit complex that directly recognises promoter elements and recruits TFIIIB and RNA polymerase III, being absolutely required for RNA polymerase III transcription. TFIIIC90 has an intrinsic histone acetyltransferase activity with a substrate specificity for histone H3 [[cite:PUB00056254]]. This domain is likely to be involved in the interaction with other components of the TFIIIC complex.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00056254":{"PMID":10523658,"ISBN":null,"volume":"19","issue":"11","year":1999,"title":"The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.","URL":null,"raw_pages":"7697-704","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Hsieh YJ","Kundu TK","Wang Z","Kovelman R","Roeder RG."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":808,"pathways":0,"proteins":807,"proteomes":656,"sets":0,"structural_models":{"alphafold":720},"structures":3,"taxa":2039},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":660},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}