This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80 [[cite:PUB00099027]]. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle [[cite:PUB00035328]]. This domain is localised between the TROVE ([pfam:PF05731]) and DUF4062 ([pfam:PF13271]) domains.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099027":{"PMID":9020079,"ISBN":null,"volume":"275","issue":"5302","year":1997,"title":"A mammalian telomerase-associated protein.","URL":null,"raw_pages":"973-7","medline_journal":"Science","ISO_journal":"Science","authors":["Harrington L","McPhail T","Mar V","Zhou W","Oulton R","Bass MB","Arruda I","Robinson MO."],"DOI_URL":null},"PUB00035328":{"PMID":11149928,"ISBN":null,"volume":"152","issue":"1","year":2001,"title":"The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.","URL":null,"raw_pages":"157-64","medline_journal":"J Cell Biol","ISO_journal":"J. Cell Biol.","authors":["Kickhoefer VA","Liu Y","Kong LB","Snow BE","Stewart PL","Harrington L","Rome LH."],"DOI_URL":"http://dx.doi.org/10.1083/jcb.152.1.157"}},"set_info":{"accession":"CL0128","name":"vWA-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":244,"interactions":0,"matches":699,"pathways":0,"proteins":684,"proteomes":387,"sets":1,"structural_models":{"alphafold":57},"structures":0,"taxa":1447},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":543},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}