{"metadata":{"accession":"PF19318","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045696","hierarchy":null,"name":{"name":"Family of unknown function (DUF5918)","short":"DUF5918"},"description":[{"text":"<p>This family represents the N-terminal domain of the RING finger protein 37 (RNF37), an  U-box domain-containing protein. This is a variable region that probably has a role in function regulation [[cite:PUB00054319]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00054319":{"PMID":20017557,"ISBN":null,"volume":"49","issue":"2","year":2010,"title":"Structural and functional characterization of the monomeric U-box domain from E4B.","URL":null,"raw_pages":"347-55","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Nordquist KA","Dimitrova YN","Brzovic PS","Ridenour WB","Munro KA","Soss SE","Caprioli RM","Klevit RE","Chazin WJ."],"DOI_URL":"http://dx.doi.org/10.1021/bi901620v"}},"set_info":{"accession":"CL0202","name":"GBD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":36,"interactions":0,"matches":1492,"pathways":0,"proteins":1357,"proteomes":1020,"sets":1,"structural_models":{"alphafold":1204},"structures":0,"taxa":3390},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":1183},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}