{"metadata":{"accession":"PF19296","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045600","hierarchy":null,"name":{"name":"RelA/SpoT AH domain","short":"RelA_AH"},"description":[{"text":"<p>This entry represents the alpha helical (AH) domain found in RelA/SpoT proteins, adjacent to the ACT domain [[cite:PUB00095792],[cite:PUB00098872]]. The AH domain interacts with A/R tRNA and links the very C-terminal subdomains with TGS domain. RelA/SpoT-homologue proteins (RHS) mediate the stringent response in bacteria which enables its metabolic adaptation under stress conditions. These enzymes synthesise the second messenger (p)ppGpp, which is a regulatory metabolite of the stringent response characterised by growth arrest and the modulation of gene expression in response to various nutritional stresses [[cite:PUB00095792],[cite:PUB00098872],[cite:PUB00059269]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00095792":{"PMID":27434674,"ISBN":null,"volume":"5","issue":null,"year":2016,"title":"Ribosome•RelA structures reveal the mechanism of stringent response activation.","URL":null,"raw_pages":null,"medline_journal":"Elife","ISO_journal":"Elife","authors":["Loveland AB","Bah E","Madireddy R","Zhang Y","Brilot AF","Grigorieff N","Korostelev AA."],"DOI_URL":null},"PUB00098872":{"PMID":32937119,"ISBN":null,"volume":"32","issue":"11","year":2020,"title":"Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.","URL":null,"raw_pages":"108157","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Pausch P","Abdelshahid M","Steinchen W","Schafer H","Gratani FL","Freibert SA","Wolz C","Turgay K","Wilson DN","Bange G."],"DOI_URL":null},"PUB00059269":{"PMID":15866041,"ISBN":null,"volume":"13","issue":"5","year":2005,"title":"ppGpp: a global regulator in Escherichia coli.","URL":null,"raw_pages":"236-42","medline_journal":"Trends Microbiol","ISO_journal":"Trends Microbiol.","authors":["Magnusson LU","Farewell A","Nystrom T."],"DOI_URL":"http://dx.doi.org/10.1016/j.tim.2005.03.008"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":39,"interactions":0,"matches":18698,"pathways":0,"proteins":18698,"proteomes":15805,"sets":0,"structural_models":{"alphafold":11911},"structures":9,"taxa":21983},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":330,"alignment:full":9123},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}