{"metadata":{"accession":"PF19213","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR043610","hierarchy":null,"name":{"name":"Coronavirus replicase NSP6","short":"CoV_NSP6"},"description":[{"text":"<p>This entry represents proteins found in Coronaviruses and includes the Non-structural Protein 6 (NSP6). Coronaviruses encode large replicase polyproteins which are proteolytically processed by viral proteases to generate mature Nonstructural Proteins (NSPs) [[cite:PUB00094417]]. NSP6 is a membrane protein containing 6 transmembrane domains with a large C-terminal tail [[cite:PUB00094417]]. NSP6 from  the avian coronavirus, infectious bronchitis  virus (IBV) and the mouse hepatitis virus (MHV) have been shown  to localise to the ER and to generate autophagosomes [[cite:PUB00094416]].  Coronavirus NSP6 proteins have also been shown to limit  autophagosome expansion. This may favour coronavirus infection  by reducing the ability of autophagosomes to deliver viral  components to lysosomes for degradation [[cite:PUB00094416]]. NSP6 from IBV, MHV  and severe acute respiratory syndrome coronavirus (SARS-CoV)  have also been found to activate autophagy [[cite:PUB00094416],[cite:PUB00094418]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00094418":{"PMID":21799305,"ISBN":null,"volume":"7","issue":"11","year":2011,"title":"Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate.","URL":null,"raw_pages":"1335-47","medline_journal":"Autophagy","ISO_journal":"Autophagy","authors":["Cottam EM","Maier HJ","Manifava M","Vaux LC","Chandra-Schoenfelder P","Gerner W","Britton P","Ktistakis NT","Wileman T."],"DOI_URL":null},"PUB00094417":{"PMID":19386712,"ISBN":null,"volume":"83","issue":"13","year":2009,"title":"Detection of nonstructural protein 6 in murine coronavirus-infected cells and analysis of the transmembrane topology by using bioinformatics and molecular approaches.","URL":null,"raw_pages":"6957-62","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Baliji S","Cammer SA","Sobral B","Baker SC."],"DOI_URL":null},"PUB00094416":{"PMID":24991833,"ISBN":null,"volume":"10","issue":"8","year":2014,"title":"Coronavirus NSP6 restricts autophagosome expansion.","URL":null,"raw_pages":"1426-41","medline_journal":"Autophagy","ISO_journal":"Autophagy","authors":["Cottam EM","Whelband MC","Wileman T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":81,"interactions":0,"matches":1387,"pathways":0,"proteins":1387,"proteomes":59,"sets":0,"structural_models":{"alphafold":81},"structures":0,"taxa":328},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":91},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}