{"metadata":{"accession":"PF19158","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR031036","hierarchy":null,"name":{"name":"Family of unknown function (DUF5840)","short":"DUF5840"},"description":[{"text":"<p>This family contains uncharacterised proteins. It also contains the anacyclamide synthesis protein AcyE. Cyanobactins are small, cyclic peptides found in cyanobacteria. They are ribosomally synthesised and post-translationally modified. Cyanobactin biosynthesis clusters contain 7-12 genes [[cite:PUB00060495]]. Anaclyclamides are a  type of cyanobactin produced in strains of the cyanobacteria Anabaena [[cite:PUB00060495]]. AcyE is a 49-amino-acid protein with N-terminal homology to the peptide precursor proteins in the other cyanobactin  pathways [[cite:PUB00094616]]. The core peptide of AcyE is cleaved during  post-translational processing of the precursor peptide [[cite:PUB00094616]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00094616":{"PMID":30266955,"ISBN":null,"volume":"8","issue":"1","year":2018,"title":"Sphaerocyclamide, a prenylated cyanobactin from the cyanobacterium Sphaerospermopsis sp. LEGE 00249.","URL":null,"raw_pages":"14537","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Martins J","Leikoski N","Wahlsten M","Azevedo J","Antunes J","Jokela J","Sivonen K","Vasconcelos V","Fewer DP","Leao PN."],"DOI_URL":null},"PUB00060495":{"PMID":20008171,"ISBN":null,"volume":"76","issue":"3","year":2010,"title":"Highly diverse cyanobactins in strains of the genus Anabaena.","URL":null,"raw_pages":"701-9","medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl. Environ. Microbiol.","authors":["Leikoski N","Fewer DP","Jokela J","Wahlsten M","Rouhiainen L","Sivonen K."],"DOI_URL":"http://dx.doi.org/10.1128/AEM.01061-09"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":74,"pathways":0,"proteins":74,"proteomes":22,"sets":0,"structural_models":{"alphafold":55},"structures":0,"taxa":122},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":10},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}