{"metadata":{"accession":"PF19151","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR026479","hierarchy":null,"name":{"name":"Sublancin","short":"Sublancin"},"description":[{"text":"<p>This family represents sublancin, a small bacteriocin active against  Gram-positive bacteria. This family appears to be restricted to  Bacilli. Sublancin was thought to be a lantibiotic but was later  shown to be an S-linked glycopeptide [[cite:PUB00060499],[cite:PUB00094614]]. Glycosylation is  essential for its antimicrobial activity. Sublancin is  biosynthesised as a precursor peptide bearing an N-terminal leader  peptide, and a C-terminal core peptide that is converted into the  mature peptide [[cite:PUB00060499]]. Sublancin comprises two alpha helices and a  well-defined inter-helical loop [[cite:PUB00094615]]. Sublancin inhibits B.cereus  spore outgrowth, after the germination stage, approximately  1000-fold better than it inhibits exponential growth of the same  cells and inhibits B.subtilis strain ATCC6633 and B. megaterium strain 14581 [[cite:PUB00094614]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00060499":{"PMID":21196935,"ISBN":null,"volume":"7","issue":"2","year":2011,"title":"Sublancin is not a lantibiotic but an S-linked glycopeptide.","URL":null,"raw_pages":"78-80","medline_journal":"Nat Chem Biol","ISO_journal":"Nat. Chem. Biol.","authors":["Oman TJ","Boettcher JM","Wang H","Okalibe XN","van der Donk WA."],"DOI_URL":"http://dx.doi.org/10.1038/nchembio.509"},"PUB00094614":{"PMID":9722542,"ISBN":null,"volume":"273","issue":"36","year":1998,"title":"Identification and characterization of the structural and transporter genes for, and the chemical and biological properties of, sublancin 168, a novel lantibiotic produced by Bacillus subtilis 168.","URL":null,"raw_pages":"23134-42","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Paik SH","Chakicherla A","Hansen JN."],"DOI_URL":null},"PUB00094615":{"PMID":24405370,"ISBN":null,"volume":"9","issue":"3","year":2014,"title":"NMR structure of the S-linked glycopeptide sublancin 168.","URL":null,"raw_pages":"796-801","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem. Biol.","authors":["Garcia De Gonzalo CV","Zhu L","Oman TJ","van der Donk WA."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":5,"pathways":0,"proteins":5,"proteomes":5,"sets":0,"structural_models":{"alphafold":3},"structures":1,"taxa":28},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":5},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}