This is a highly conserved domain found in various Platyhelminthes. Its function is currently unknown, with some of the sequences annotated as being Palmitoyltransferase. This highly conserved domain is located at the amino terminus, next to a DHHC domain (named for its signature tetrapeptide Asp-His-His-Cys).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0117","name":"uPAR_Ly6_toxin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":39,"pathways":0,"proteins":37,"proteomes":32,"sets":1,"structural_models":{"alphafold":33},"structures":0,"taxa":92},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":30},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}