{"metadata":{"accession":"PF18882","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR043707","hierarchy":null,"name":{"name":"Family of unknown function (DUF5647)","short":"DUF5647"},"description":[{"text":"<p>This is a family of unknown function. Family members include the hypothetical protein TTHC002 from Thermus thermophilus. Its has an alpha-beta-alpha-beta(3) structure and forms a dimer with a single beta-sheet, folded in a barrel-like shape [[cite:PUB00094504]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00094504":{"PMID":23574940,"ISBN":null,"volume":"14","issue":"4","year":2013,"title":"Recurrent structural motifs in non-homologous protein structures.","URL":null,"raw_pages":"7795-814","medline_journal":"Int J Mol Sci","ISO_journal":"Int J Mol Sci","authors":["Johansson MU","Zoete V","Guex N."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":33,"pathways":0,"proteins":33,"proteomes":18,"sets":0,"structural_models":{"alphafold":26},"structures":1,"taxa":77},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":25},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}