This is a family of unknown function. Family members include the archaeal homolog the bacterial RelB, a toxin-antitoxin system which is activated during amino acid starvation. This family is mostly found in thermococcus archaea [[cite:PUB00038109]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00038109":{"PMID":15768033,"ISBN":null,"volume":"12","issue":"4","year":2005,"title":"Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects.","URL":null,"raw_pages":"327-31","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Takagi H","Kakuta Y","Okada T","Yao M","Tanaka I","Kimura M."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb911"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":8,"pathways":0,"proteins":8,"proteomes":8,"sets":0,"structural_models":{"alphafold":8},"structures":1,"taxa":27},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":3},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}