This domain is found in proteins of unknown function. It has composed of eight antiparallel beta strands and carries a G-X-W motif in the N-terminal region. The conserved glycine-X-tryptophan (G-X-W) motif is characteristic for the lipocalin family [[cite:PUB00091384]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00091384":{"PMID":23738031,"ISBN":null,"volume":"4","issue":"4","year":2011,"title":"Significance of G-X-W motif in the myocilin olfactomedin domain.","URL":null,"raw_pages":"154-8","medline_journal":"J Ocul Biol Dis Infor","ISO_journal":"J Ocul Biol Dis Infor","authors":["Rangachari K","Jeyalaxmi J","Eswari Pandaranayaka PJ","Prasanthi N","Sundaresan P","Krishnadas SR","Krishnaswamy S."],"DOI_URL":"https://doi.org/10.1007/s12177-012-9089-7"}},"set_info":{"accession":"CL0116","name":"Calycin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":40,"pathways":0,"proteins":40,"proteomes":37,"sets":1,"structural_models":{"alphafold":26},"structures":1,"taxa":94},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":27},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}