This is a domain of unknown function found in archaea-specific ribosomal proteins such as L46a which is suggested to directly bind to rRNA in the ribosome [[cite:PUB00091411]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00091411":{"PMID":24875358,"ISBN":null,"volume":"450","issue":"1","year":2014,"title":"Structure determination of archaea-specific ribosomal protein L46a reveals a novel protein fold.","URL":null,"raw_pages":"67-72","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem. Biophys. Res. Commun.","authors":["Feng Y","Song X","Lin J","Xuan J","Cui Q","Wang J."],"DOI_URL":"https://doi.org/10.1016/j.bbrc.2014.05.077"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":45,"pathways":0,"proteins":45,"proteomes":44,"sets":0,"structural_models":{"alphafold":44},"structures":10,"taxa":102},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":26},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}