This domain of unknown function is found at the C-terminal end of proteins mainly from Legionella, including lpg0944 from Legionella pneumophila ([swissprot:Q5ZWY9]), which is thought to be an effector of the Icm/Dot translocation system from this bacteria. This domain folds into an all-alpha structure [[cite:PUB00091363]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00091363":{"PMID":27986836,"ISBN":null,"volume":"12","issue":"12","year":2016,"title":"Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila.","URL":null,"raw_pages":"893","medline_journal":"Mol Syst Biol","ISO_journal":"Mol. Syst. Biol.","authors":["Urbanus ML","Quaile AT","Stogios PJ","Morar M","Rao C","Di Leo R","Evdokimova E","Lam M","Oatway C","Cuff ME","Osipiuk J","Michalska K","Nocek BP","Taipale M","Savchenko A","Ensminger AW."],"DOI_URL":"https://doi.org/10.15252/msb.20167381"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":12,"interactions":0,"matches":128,"pathways":0,"proteins":128,"proteomes":50,"sets":0,"structural_models":{"alphafold":93},"structures":2,"taxa":69},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":46},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4wrp","name":"The C-terminal domain of gene product lpg0944 from Legionella pneumophila subsp. pneumophila str. Philadelphia 1"}}}