This is a domain of unknown function. Studies of the TA0095 gene product indicate that this 96-residue hypothetical protein from Thermoplasma acidophilum is a member of the COG4004 orthologous group of unknown function found in Archaea bacteria. The structure displays an alpha/beta two-layer sandwich architecture formed by three alpha-helices and five beta-strands. Furthermore, structural homologs indicate that the TA0095 structure belongs to the TBP-like fold [[cite:PUB00047999]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00047999":{"PMID":17766377,"ISBN":null,"volume":"16","issue":"10","year":2007,"title":"Solution structure of the hypothetical protein TA0095 from Thermoplasma acidophilum: a novel superfamily with a two-layer sandwich architecture.","URL":null,"raw_pages":"2278-86","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Leon E","Yee A","Ortiz AR","Santoro J","Rico M","Jimenez MA."],"DOI_URL":"http://dx.doi.org/10.1110/ps.072869607"}},"set_info":{"accession":"CL0407","name":"TBP-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":400,"pathways":0,"proteins":400,"proteomes":400,"sets":1,"structural_models":{"alphafold":374},"structures":1,"taxa":674},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":37,"alignment:full":191},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}