This domain is often found in the N-terminal region of proteins carrying the SET domain ([pfam:PF00856]), such as the SETDB1 protein present in Homo sapiens. SETDB1 is a histone methyltransferase that suppresses gene expression and modulates heterochromatin formation through H3K9me2/3 [[cite:PUB00091314]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00091314":{"PMID":28420800,"ISBN":null,"volume":"154","issue":"1","year":2017,"title":"SETDB1 plays an essential role in maintenance of gonocyte survival in pigs.","URL":null,"raw_pages":"23-34","medline_journal":"Reproduction","ISO_journal":"Reproduction","authors":["Liu T","Zhang P","Li T","Chen X","Zhu Z","Lyu Y","Li X","Tian X","Zeng W."],"DOI_URL":"https://doi.org/10.1530/REP-17-0107"}},"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":50,"interactions":0,"matches":1296,"pathways":0,"proteins":1278,"proteomes":604,"sets":1,"structural_models":{"alphafold":821},"structures":24,"taxa":1964},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":1022},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}