{"metadata":{"accession":"PF18151","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR041545","hierarchy":null,"name":{"name":"Domain of unknown function (DUF5601)","short":"DUF5601"},"description":[{"text":"<p>This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature [[cite:PUB00042275]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00042275":{"PMID":17450153,"ISBN":null,"volume":"14","issue":"5","year":2007,"title":"Structural basis for Rab GTPase activation by VPS9 domain exchange factors.","URL":null,"raw_pages":"406-12","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Delprato A","Lambright DG."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb1232"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":99,"interactions":0,"matches":6758,"pathways":0,"proteins":6756,"proteomes":3165,"sets":0,"structural_models":{"alphafold":4099},"structures":9,"taxa":8367},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":5156},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}