This domain can be found in EH-domain-containing ATPase 2 (EHD2) present in Mus musculus. The domain is helical in nature and has extensive contacts with the G-domain [[cite:PUB00049104]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00049104":{"PMID":17914359,"ISBN":null,"volume":null,"issue":null,"year":2007,"title":"Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling.","URL":null,"raw_pages":null,"medline_journal":"Nature","ISO_journal":"Nature","authors":["Daumke O","Lundmark R","Vallis Y","Martens S","Butler PJ","McMahon HT."],"DOI_URL":null},"PUB00072531":{"PMID":24508342,"ISBN":null,"volume":"22","issue":"3","year":2014,"title":"Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2.","URL":null,"raw_pages":"409-20","medline_journal":"Structure","ISO_journal":"Structure","authors":["Shah C","Hegde BG","Moren B","Behrmann E","Mielke T","Moenke G","Spahn CM","Lundmark R","Daumke O","Langen R."],"DOI_URL":"http://dx.doi.org/10.1016/j.str.2013.12.015"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":117,"interactions":0,"matches":6295,"pathways":0,"proteins":6255,"proteomes":1994,"sets":0,"structural_models":{"alphafold":5405},"structures":5,"taxa":6071},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":4693},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}