{"metadata":{"accession":"PF18141","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR040812","hierarchy":null,"name":{"name":"RNA helicase UPF1, 1B domain","short":"UPF1_1B_dom"},"description":[{"text":"<p>UPF1 (or regulator of nonsense transcripts 1 homologue) is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation. Together with UPF2 and UPF3, forms a surveillance complex, in which UPF2 acts as a bridge between UPF1 and UPF3. UPF2 and UPF3 are non-enzymatic components of the complex that stimulate the activity of UPF1 [[cite:PUB00050141],[cite:PUB00095891]]. UPF1 has a N-terminal cysteine/histidine-rich zinc-binding domain (CH/ZBD), a regulatory 1B domain, followed by a helicase core that belongs to superfamily 1 (SF1). This entry represents 1B domain of UPF1 which has a regulatory role. It suffers conformational changes from an inhibitory state to a transition-state complex that modulate RNA binding [[cite:PUB00050141],[cite:PUB00095891]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00050141":{"PMID":19556969,"ISBN":null,"volume":null,"issue":null,"year":2009,"title":"Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.","URL":null,"raw_pages":null,"medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Clerici M","Mourao A","Gutsche I","Gehring NH","Hentze MW","Kulozik A","Kadlec J","Sattler M","Cusack S."],"DOI_URL":null},"PUB00095891":{"PMID":21419344,"ISBN":null,"volume":"41","issue":"6","year":2011,"title":"Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.","URL":null,"raw_pages":"693-703","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Chakrabarti S","Jayachandran U","Bonneau F","Fiorini F","Basquin C","Domcke S","Le Hir H","Conti E."],"DOI_URL":null}},"set_info":{"accession":"CL0866","name":"ALR_C-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":89,"interactions":0,"matches":3790,"pathways":0,"proteins":3779,"proteomes":2612,"sets":1,"structural_models":{"alphafold":3031},"structures":12,"taxa":7201},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":2836},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}