{"metadata":{"accession":"PF18127","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR041529","hierarchy":null,"name":{"name":"Nicotinamide phosphoribosyltransferase, N-terminal domain","short":"NAMPT_N"},"description":[{"text":"<p>This is the N-terminal domain found in Nicotinamide phosphoribosyltransferase (NAMPT) present in Homo sapiens. NAMPT captures nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD+) pool during ADP-ribosylation and transferase reactions [[cite:PUB00059630]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00059630":{"PMID":19819904,"ISBN":null,"volume":"147","issue":"1","year":2010,"title":"Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase.","URL":null,"raw_pages":"95-107","medline_journal":"J Biochem","ISO_journal":"J. Biochem.","authors":["Takahashi R","Nakamura S","Nakazawa T","Minoura K","Yoshida T","Nishi Y","Kobayashi Y","Ohkubo T."],"DOI_URL":"http://dx.doi.org/10.1093/jb/mvp152"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":36,"interactions":0,"matches":3729,"pathways":0,"proteins":3721,"proteomes":2538,"sets":0,"structural_models":{"alphafold":2846},"structures":99,"taxa":5725},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":2453},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}