This domain is found in Nude C 80 (Ndc80) proteins which can be found in species such as Homo sapiens. Ndc80 protein complexes are a core component of the end-on attachment sites for kinetochore microtubules. Ndc80 is also known as Hec1, for highly expressed in cancer 1 [[cite:PUB00049694]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00049694":{"PMID":18455984,"ISBN":null,"volume":"133","issue":"3","year":2008,"title":"Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.","URL":null,"raw_pages":"427-39","medline_journal":"Cell","ISO_journal":"Cell","authors":["Ciferri C","Pasqualato S","Screpanti E","Varetti G","Santaguida S","Dos Reis G","Maiolica A","Polka J","De Luca JG","De Wulf P","Salek M","Rappsilber J","Moores CA","Salmon ED","Musacchio A."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2008.03.020"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":23,"interactions":0,"matches":1048,"pathways":0,"proteins":1048,"proteomes":866,"sets":0,"structural_models":{"alphafold":931},"structures":12,"taxa":2717},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":872},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}