This domain was first discovered in BPSL1050, a highly immunoreactive protein found in Burkholderia pseudomallei. The domain's structure consists of three helical regions which pack onto an antiparallel beta sheet, formed by four strands. The beta sheet is solvent exposed on one side and packs tightly against the three helices on the other side, generating a network of hydrophobic and aromatic interactions that contribute to tight packing of the protein. Is is thought that the small loop L1, the main loop L2, and part of helix alpha-3 extending until Leu120 are the three main immunogenic sequences [[cite:PUB00091370]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00091370":{"PMID":25495888,"ISBN":null,"volume":"10","issue":"3","year":2015,"title":"Structure-based design of a B cell antigen from B. pseudomallei.","URL":null,"raw_pages":"803-12","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem. Biol.","authors":["Gaudesi D","Peri C","Quilici G","Gori A","Ferrer-Navarro M","Conchillo-Sole O","Thomas R","Nithichanon A","Lertmemongkolchai G","Titball R","Daura X","Colombo G","Musco G."],"DOI_URL":"https://doi.org/10.1021/cb500831y"}},"set_info":{"accession":"CL1008","name":"DUF3022-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":200,"pathways":0,"proteins":200,"proteomes":169,"sets":1,"structural_models":{"alphafold":139},"structures":1,"taxa":192},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":37,"alignment:full":60},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}