{"metadata":{"accession":"PF17722","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR040028","hierarchy":null,"name":{"name":"Intraflagellar transport-associated protein","short":"IFTAP"},"description":[{"text":"<p>Intraflagellar transport-associated protein (IFTAP, C11ORF74) interacts with the IFT-A complex and is accumulated at the distal tip in the absence of an IFT-A subunit IFT139. In IFTAP-knockout (KO) cells, the BBSome components cannot enter cilia. However, IFTAP-KO mice demonstrated no obvious anatomical abnormalities associated with ciliary dysfunctions [[cite:PUB00093954]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093954":{"PMID":30476139,"ISBN":null,"volume":"165","issue":"3","year":2019,"title":"C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization.","URL":null,"raw_pages":"257-267","medline_journal":"J Biochem","ISO_journal":"J. Biochem.","authors":["Takahara M","Kunii M","Nakamura K","Harada A","Hirano T","Katoh Y","Nakayama K."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":673,"pathways":0,"proteins":605,"proteomes":352,"sets":0,"structural_models":{"alphafold":519},"structures":0,"taxa":1234},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":622},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}