{"metadata":{"accession":"PF17720","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR041211","hierarchy":null,"name":{"name":"RNA ligase 1","short":"RLIG1"},"description":[{"text":"<p>This entry includes RNA ligase 1 from animals (RLIG1), which functions as an RNA ligase in vitro [[cite:PUB00151146]]. This protein catalyses ATP-dependent RNA ligation via a three-step mechanism, involving tandem auto- and RNA AMPylation. It exhibits selectivity for single-stranded RNA substrates. RLIG1 may play a role in maintaining RNA integrity under stress conditions, such as in response to reactive oxygen species (ROS) [[cite:PUB00151146]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151146":{"PMID":36792600,"ISBN":null,"volume":"14","issue":"1","year":2023,"title":"Chemoproteomic discovery of a human RNA ligase.","URL":null,"raw_pages":"842","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Yuan Y","Stumpf FM","Schlor LA","Schmidt OP","Saumer P","Huber LB","Frese M","Hollmuller E","Scheffner M","Stengel F","Diederichs K","Marx A."],"DOI_URL":null}},"set_info":{"accession":"CL0179","name":"ATP-grasp"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":923,"pathways":0,"proteins":882,"proteomes":614,"sets":1,"structural_models":{"alphafold":721},"structures":2,"taxa":2034},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":682},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}