{"metadata":{"accession":"PF17685","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR041156","hierarchy":null,"name":{"name":"Transmembrane protein 250","short":"TM250"},"description":[{"text":"<p>This family includes human Transmembrane protein 250 (TM250) and similar proteins from vertebrates. TM250 is involved in cellular processes related to cell proliferation, specifically by aiding the transition into the S phase of the cell cycle. Additionally, it has a role in viral pathogenesis, as it is known to enhance the proliferation of human herpes simplex virus 1 (HHV-1) [[cite:PUB00155240]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155240":{"PMID":21667337,"ISBN":null,"volume":"26","issue":"3","year":2011,"title":"Host cell protein C9orf69 promotes viral proliferation via interaction with HSV-1 UL25 protein.","URL":null,"raw_pages":"171-80","medline_journal":"Virol Sin","ISO_journal":"Virol Sin","authors":["Zhang Y","Li YM","Liu LD","Jiang L","Ji M","Jiang RJ","Guo L","Liao Y","Li QH."],"DOI_URL":"https://doi.org/10.1007/s12250-011-3179-8"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":698,"pathways":0,"proteins":696,"proteomes":656,"sets":0,"structural_models":{"alphafold":634},"structures":0,"taxa":2055},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":585},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}