{"metadata":{"accession":"PF17672","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR038813","hierarchy":null,"name":{"name":"Fertilisation-influencing membrane protein","short":"FIMP"},"description":[{"text":"<p>In mice, 4930451I11Rik encodes two isoforms: a transmembrane (TM) form and a secreted form. FIMP is the TM form. It is a sperm-specific transmembrane protein that is essential for the sperm-oocyte fusion process [[cite:PUB00095075]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00095075":{"PMID":32295885,"ISBN":null,"volume":"117","issue":"17","year":2020,"title":"Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice.","URL":null,"raw_pages":"9393-9400","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Fujihara Y","Lu Y","Noda T","Oji A","Larasati T","Kojima-Kita K","Yu Z","Matzuk RM","Matzuk MM","Ikawa M."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":153,"pathways":0,"proteins":150,"proteomes":132,"sets":0,"structural_models":{"alphafold":126},"structures":0,"taxa":464},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":132},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}