This is a family of unknown function. Family members are found in Bacteria and Eukaryotes. In algae, this family is found on the N-terminal of diphthamide synthase family [pfam:PF01902] and is predicted to be a membrane transporter belonging to The ATP-binding Cassette (ABC) family [[cite:PUB00091274]]. In nematoda, it is found on the N-terminal side of ribosomal protein family L14 [pfam:PF00238]. It is also found on the N-terminal of Cob(I)alamin adenosyltransferase [pfam:PF01923] in other eukaryotes. Family members found in homo sapiens such as [swissprot:Q5VUE5], have been shown to be highly expressed in 15 high-grade neuroendocrine tumor cell lines and YAP1-positive small-cell lung cancer cell lines [[cite:PUB00091275]] as well as being up-regulated in two human Multiple Myloma cell lines in response to selective nuclear export inhibitor KPT-276 [[cite:PUB00091276]]. The HMM profile of this family reveals 4 highly conserved cysteines.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00091275":{"PMID":27418196,"ISBN":null,"volume":"107","issue":"10","year":2016,"title":"Loss of YAP1 defines neuroendocrine differentiation of lung tumors.","URL":null,"raw_pages":"1527-1538","medline_journal":"Cancer Sci","ISO_journal":"Cancer Sci.","authors":["Ito T","Matsubara D","Tanaka I","Makiya K","Tanei ZI","Kumagai Y","Shiu SJ","Nakaoka HJ","Ishikawa S","Isagawa T","Morikawa T","Shinozaki-Ushiku A","Goto Y","Nakano T","Tsuchiya T","Tsubochi H","Komura D","Aburatani H","Dobashi Y","Nakajima J","Endo S","Fukayama M","Sekido Y","Niki T","Murakami Y."],"DOI_URL":"https://doi.org/10.1111/cas.13013"},"PUB00091276":{"PMID":23752175,"ISBN":null,"volume":"27","issue":"12","year":2013,"title":"Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276.","URL":null,"raw_pages":"2357-65","medline_journal":"Leukemia","ISO_journal":"Leukemia","authors":["Schmidt J","Braggio E","Kortuem KM","Egan JB","Zhu YX","Xin CS","Tiedemann RE","Palmer SE","Garbitt VM","McCauley D","Kauffman M","Shacham S","Chesi M","Bergsagel PL","Stewart AK."],"DOI_URL":"https://doi.org/10.1038/leu.2013.172"},"PUB00091274":{"PMID":22195008,"ISBN":null,"volume":"6","issue":"12","year":2011,"title":"Red and green algal origin of diatom membrane transporters: insights into environmental adaptation and cell evolution.","URL":null,"raw_pages":"e29138","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Chan CX","Reyes-Prieto A","Bhattacharya D."],"DOI_URL":"https://doi.org/10.1371/journal.pone.0029138"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":2412,"pathways":0,"proteins":2412,"proteomes":2151,"sets":0,"structural_models":{"alphafold":1609},"structures":0,"taxa":4314},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":58,"alignment:full":1214},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}