{"metadata":{"accession":"PF17495","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR035276","hierarchy":null,"name":{"name":"Vpr-like OrfA","short":"OrfA"},"description":[{"text":"<p>Family members include OrfA protein, a multifunctional accessory protein found in Feline immunodeficiency virus (FIV), a lentivirus that causes AIDS in domestic cats [[cite:PUB00085284]]. Multiple potential functions have been ascribed to OrfA, including transactivation of viral protein expression [[cite:PUB00085285]], effects on virion formation and infectivity [[cite:PUB00085286]], host cell cycle arrest [[cite:PUB00085291]] and downregulation of cell surface expression of the primary FIV receptor, CD134 [[cite:PUB00085287]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00085286":{"PMID":12885901,"ISBN":null,"volume":"77","issue":"16","year":2003,"title":"Feline immunodeficiency virus ORF-Ais required for virus particle formation and virus infectivity.","URL":null,"raw_pages":"8819-30","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Gemeniano MC","Sawai ET","Leutenegger CM","Sparger EE."],"DOI_URL":"https://doi.org/10.1128/JVI.77.16.8819-8830.2003"},"PUB00085291":{"PMID":15246256,"ISBN":null,"volume":"325","issue":"2","year":2004,"title":"Feline immunodeficiency virus Orf-A localizes to the nucleus and induces cell cycle arrest.","URL":null,"raw_pages":"167-74","medline_journal":"Virology","ISO_journal":"Virology","authors":["Gemeniano MC","Sawai ET","Sparger EE."],"DOI_URL":"https://doi.org/10.1016/j.virol.2004.05.007"},"PUB00085285":{"PMID":9847366,"ISBN":null,"volume":"73","issue":"1","year":1999,"title":"Demonstration that orf2 encodes the feline immunodeficiency virus transactivating (Tat) protein and characterization of a unique gene product with partial rev activity.","URL":null,"raw_pages":"608-17","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["de Parseval A","Elder JH."],"DOI_URL":null},"PUB00085287":{"PMID":20463078,"ISBN":null,"volume":"84","issue":"14","year":2010,"title":"OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.","URL":null,"raw_pages":"7225-32","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Hong Y","Fink E","Hu QY","Kiosses WB","Elder JH."],"DOI_URL":"https://doi.org/10.1128/JVI.00434-10"},"PUB00085284":{"PMID":23658451,"ISBN":null,"volume":"87","issue":"14","year":2013,"title":"Accessory genes confer a high replication rate to virulent feline immunodeficiency virus.","URL":null,"raw_pages":"7940-51","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Troyer RM","Thompson J","Elder JH","VandeWoude S."],"DOI_URL":"https://doi.org/10.1128/JVI.00752-13"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":14,"pathways":0,"proteins":14,"proteomes":0,"sets":0,"structural_models":{"alphafold":1},"structures":0,"taxa":13},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":0},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}