This is a Bacterial family of unknown function. Family members are predicted to belong to Type VII secretion (T7S) system. There is a conserved YxxxD/E sequence. It is a general secretion signal that is present in all known mycobacterial T7S substrates or substrate complexes [[cite:PUB00099431]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00099431":{"PMID":22733768,"ISBN":null,"volume":"109","issue":"28","year":2012,"title":"General secretion signal for the mycobacterial type VII secretion pathway.","URL":null,"raw_pages":"11342-7","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Daleke MH","Ummels R","Bawono P","Heringa J","Vandenbroucke-Grauls CM","Luirink J","Bitter W."],"DOI_URL":null}},"set_info":{"accession":"CL0352","name":"EsxAB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":396,"pathways":0,"proteins":396,"proteomes":221,"sets":1,"structural_models":{"alphafold":233},"structures":0,"taxa":343},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":186},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}