{"metadata":{"accession":"PF17266","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR035161","hierarchy":null,"name":{"name":"Family of unknown function (DUF5332)","short":"DUF5332"},"description":[{"text":"<p>This family of uncharacterized proteins is mostly found in Chromadorea. Family members include dct-5 proteins. Dct-5 is a target of DAF-16, a forkhead transcription factor, which is a key regulator of longevity, metabolism and dauer diapause in Caenorhabditis elegans [[cite:PUB00045322]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00045322":{"PMID":16380712,"ISBN":null,"volume":"38","issue":"2","year":2006,"title":"Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.","URL":null,"raw_pages":"251-7","medline_journal":"Nat Genet","ISO_journal":"Nat. Genet.","authors":["Oh SW","Mukhopadhyay A","Dixit BL","Raha T","Green MR","Tissenbaum HA."],"DOI_URL":"http://dx.doi.org/10.1038/ng1723"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":187,"pathways":0,"proteins":186,"proteomes":90,"sets":0,"structural_models":{"alphafold":178},"structures":0,"taxa":210},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":143},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}