This family of unknown function is mostly found in Actinobacteria. Its fold was identified as part of the zinc-ribbon superfamily [[cite:PUB00152793],[cite:PUB00017144]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00152793":{"PMID":36419248,"ISBN":null,"volume":"32","issue":"1","year":2023,"title":"DALI shines a light on remote homologs: One hundred discoveries.","URL":null,"raw_pages":"e4519","medline_journal":"Protein Sci","ISO_journal":"Protein Sci","authors":["Holm L","Laiho A","Toronen P","Salgado M."],"DOI_URL":"https://doi.org/10.1002/pro.4519"},"PUB00017144":{"PMID":10873443,"ISBN":null,"volume":"299","issue":"5","year":2000,"title":"C-terminal domains of Escherichia coli topoisomerase I belong to the zinc-ribbon superfamily.","URL":null,"raw_pages":"1165-77","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Grishin NV."],"DOI_URL":"http://dx.doi.org/10.1006/jmbi.2000.3841"}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":1443,"pathways":0,"proteins":1443,"proteomes":1438,"sets":1,"structural_models":{"alphafold":945},"structures":0,"taxa":1799},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":644},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}