{"metadata":{"accession":"PF17237","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR035195","hierarchy":null,"name":{"name":"ERMES regulator 1","short":"Emr1"},"description":[{"text":"<p>The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex creates contact sites between the endoplasmic reticulum and mitochondria, playing crucial roles in interorganelle communication, mitochondrial fission, mtDNA inheritance, lipid transfer, and autophagy. Emr1, also known as Mco6 in budding yeasts, mediates the formation ERMES foci, thereby contributing to the formation of ER-mitochondrial contact sites [[cite:PUB00099560]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00099560":{"PMID":33483504,"ISBN":null,"volume":"12","issue":"1","year":2021,"title":"Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.","URL":null,"raw_pages":"521","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Rasul F","Zheng F","Dong F","He J","Liu L","Liu W","Cheema JY","Wei W","Fu C."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":622,"pathways":0,"proteins":622,"proteomes":607,"sets":0,"structural_models":{"alphafold":536},"structures":0,"taxa":1555},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":488},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}