{"metadata":{"accession":"PF17229","entry_id":null,"type":"disordered","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR035175","hierarchy":null,"name":{"name":"Serine/threonine-protein kinase SMG1 N-terminal","short":"SMG1_N"},"description":[{"text":"<p>This entry represents the N-terminal disordered region of SMG1, which is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family. SMG1 associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay [[cite:PUB00085231]]. It also plays an important role in genotoxic stress responses to DNA damage [[cite:PUB00085233]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00085231":{"PMID":11544179,"ISBN":null,"volume":"15","issue":"17","year":2001,"title":"Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.","URL":null,"raw_pages":"2215-28","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Yamashita A","Ohnishi T","Kashima I","Taya Y","Ohno S."],"DOI_URL":"https://doi.org/10.1101/gad.913001"},"PUB00085233":{"PMID":21911475,"ISBN":null,"volume":"31","issue":"22","year":2011,"title":"A novel role for hSMG-1 in stress granule formation.","URL":null,"raw_pages":"4417-29","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Brown JA","Roberts TL","Richards R","Woods R","Birrell G","Lim YC","Ohno S","Yamashita A","Abraham RT","Gueven N","Lavin MF."],"DOI_URL":"https://doi.org/10.1128/MCB.05987-11"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":18,"interactions":0,"matches":1093,"pathways":0,"proteins":1092,"proteomes":638,"sets":0,"structural_models":{"alphafold":117},"structures":2,"taxa":2006},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":887},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}