This small family of proteins found in Clostridiales is functionally uncharacterized. Proteins in this family are around 130 amino acids in length. Based on NMR structure 2MCA, it forms a beta-sandwich structure consisting of two 4-stranded antiparallel b-strands. The structure is very similar to glutamine glutamyltransferases (1l9n) and peptide transporters (5a9h).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0287","name":"Transthyretin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":4,"pathways":0,"proteins":4,"proteomes":4,"sets":1,"structural_models":{"alphafold":3},"structures":1,"taxa":16},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":2},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}