{"metadata":{"accession":"PF17198","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR033459","hierarchy":null,"name":{"name":"Spirocyclase AveC-like","short":"AveC_like"},"description":[{"text":"<p>AveC catalyzes the stereospecific spiroketalization of a dihydroxy-ketone polyketide intermediate in the biosynthetic pathway of Avermectin, a potent antiparasitic agent. Additionally, it has a unique dehydration activity that serves to determine the regiospecific saturation pattern for spiroketal diversity [[cite:PUB00081205]]. MeiC, the counterpart in the biosynthesis of AVE-like meilingmycin, also has spirocyclase activity, but lacks the dehydratase activity.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00081205":{"PMID":23294008,"ISBN":null,"volume":"135","issue":"4","year":2013,"title":"Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC.","URL":null,"raw_pages":"1540-8","medline_journal":"J Am Chem Soc","ISO_journal":"J. Am. Chem. Soc.","authors":["Sun P","Zhao Q","Yu F","Zhang H","Wu Z","Wang Y","Wang Y","Zhang Q","Liu W."],"DOI_URL":"http://dx.doi.org/10.1021/ja311339u"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":854,"pathways":0,"proteins":854,"proteomes":334,"sets":0,"structural_models":{"alphafold":589},"structures":0,"taxa":536},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":289},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}