Proteins in this family are uncharacterised, but have been identified as members of a gene cluster for the synthesis of the tetramic-acid antibiotic streptolydigin, which inhibits bacterial RNA polymerase (RNAP) [[cite:PUB00039075]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00039075":{"PMID":16122422,"ISBN":null,"volume":"122","issue":"4","year":2005,"title":"Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.","URL":null,"raw_pages":"541-52","medline_journal":"Cell","ISO_journal":"Cell","authors":["Tuske S","Sarafianos SG","Wang X","Hudson B","Sineva E","Mukhopadhyay J","Birktoft JJ","Leroy O","Ismail S","Clark AD Jr","Dharia C","Napoli A","Laptenko O","Lee J","Borukhov S","Ebright RH","Arnold E."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2005.07.017"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":1819,"pathways":0,"proteins":1816,"proteomes":1452,"sets":0,"structural_models":{"alphafold":922},"structures":0,"taxa":1733},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":40,"alignment:full":839},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}