{"metadata":{"accession":"PF17196","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR033457","hierarchy":null,"name":{"name":"Protein of unknown function (DUF5133)","short":"DUF5133"},"description":[{"text":"<p>This protein of unknown function is part of the Borrelidin synthesis genomic cluster. Borrelidin is a polyketide antibiotic [[cite:PUB00078768],[cite:PUB00078769]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00078768":{"PMID":15186422,"ISBN":null,"volume":"52","issue":"6","year":2004,"title":"Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: insights into nitrile formation.","URL":null,"raw_pages":"1745-56","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Olano C","Moss SJ","Brana AF","Sheridan RM","Math V","Weston AJ","Mendez C","Leadlay PF","Wilkinson B","Salas JA."],"DOI_URL":"http://dx.doi.org/10.1111/j.1365-2958.2004.04090.x"},"PUB00078769":{"PMID":15112998,"ISBN":null,"volume":"11","issue":"1","year":2004,"title":"Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions.","URL":null,"raw_pages":"87-97","medline_journal":"Chem Biol","ISO_journal":"Chem. Biol.","authors":["Olano C","Wilkinson B","Sanchez C","Moss SJ","Sheridan R","Math V","Weston AJ","Brana AF","Martin CJ","Oliynyk M","Mendez C","Leadlay PF","Salas JA."],"DOI_URL":"http://dx.doi.org/10.1016/S1074-5521(03)00297-7"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":1658,"pathways":0,"proteins":1658,"proteomes":675,"sets":0,"structural_models":{"alphafold":675},"structures":0,"taxa":723},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":762},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}