{"metadata":{"accession":"PF17195","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR033456","hierarchy":null,"name":{"name":"Protein of unknown function (DUF5132)","short":"DUF5132"},"description":[{"text":"<p>Proteins in this family are uncharacterised, but have been identified as members of a gene cluster for the synthesis of Ansamitocin [[cite:PUB00078767]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00078767":{"PMID":12060743,"ISBN":null,"volume":"99","issue":"12","year":2002,"title":"The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.","URL":null,"raw_pages":"7968-73","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Yu TW","Bai L","Clade D","Hoffmann D","Toelzer S","Trinh KQ","Xu J","Moss SJ","Leistner E","Floss HG."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.092697199"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":375,"pathways":0,"proteins":375,"proteomes":255,"sets":0,"structural_models":{"alphafold":218},"structures":0,"taxa":665},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":229},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}