This family of proteins from Bacteroidetes, is found with a PKD domain at the N-terminus. Several members are annotated as putative quinonprotein alcohol dehydrogenase-like proteins but this could not be confirmed. This entry represents a beta propeller like domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00059330":{"PMID":22532667,"ISBN":null,"volume":"109","issue":"19","year":2012,"title":"A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system.","URL":null,"raw_pages":"7298-303","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Lowe EC","Basle A","Czjzek M","Firbank SJ","Bolam DN."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1200479109"},"PUB00058438":{"PMID":22120742,"ISBN":null,"volume":"67","issue":"Pt 12","year":2011,"title":"Structural basis for the DNA-binding activity of the bacterial β-propeller protein YncE.","URL":null,"raw_pages":"1045-53","medline_journal":"Acta Crystallogr D Biol Crystallogr","ISO_journal":"Acta Crystallogr. D Biol. Crystallogr.","authors":["Kagawa W","Sagawa T","Niki H","Kurumizaka H."],"DOI_URL":"http://dx.doi.org/10.1107/S0907444911045033"}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":2145,"pathways":0,"proteins":2145,"proteomes":1504,"sets":1,"structural_models":{"alphafold":1369},"structures":17,"taxa":2299},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":953},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9s6c","name":"B12 Binding protein - BtuK1"}}}