This protein family found in Chlamydia includes CT296 from Chlamydia trachomatis, which show structural features typical of non-heme Fe(II) 2-oxoglutarate-dependent enzymes [[cite:PUB00100851]]. The specific function of these proteins is not known.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00100851":{"PMID":21965559,"ISBN":null,"volume":"193","issue":"23","year":2011,"title":"Ab initio structural modeling of and experimental validation for Chlamydia trachomatis protein CT296 reveal structural similarity to Fe(II) 2-oxoglutarate-dependent enzymes.","URL":null,"raw_pages":"6517-28","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Kemege KE","Hickey JM","Lovell S","Battaile KP","Zhang Y","Hefty PS."],"DOI_URL":null}},"set_info":{"accession":"CL0029","name":"Cupin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":21,"pathways":0,"proteins":21,"proteomes":19,"sets":1,"structural_models":{"alphafold":11},"structures":2,"taxa":39},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":1},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3qh6","name":"1.8A resolution structure of CT296 from Chlamydia trachomatis"}}}