This entry represents a pair of structurally similar domains with one nested within the other. Each domain has pseudo-thteefold symmetry. This family is found fused to a copper-binding protein at the C-terminus, family Copper-bind, [pfam:PF00127]. Its function is not known, and it is found in the Halobacteriaceae family in Archaea.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":81,"pathways":0,"proteins":80,"proteomes":78,"sets":0,"structural_models":{"alphafold":74},"structures":0,"taxa":143},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":23,"alignment:full":32},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}