{"metadata":{"accession":"PF16347","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR032506","hierarchy":null,"name":{"name":"N-sulphoglucosamine sulphohydrolase, C-terminal","short":"SGSH_C"},"description":[{"text":"<p>This domain is found at the C-terminal end of sulfatases and alkaline phosphatases from bacteria, eukaryotes and archaea, including N-sulphoglucosamine sulphohydrolase from humans (SGSH) and Bifunctional sulfatase/alpha-L-rhamnosidase from Formosa agariphila (P36_S1_25). It shows a four-stranded antiparallel beta-sheet, with four surrounding alpha-helices, followed by a C-terminal extension consisting of a small two-stranded antiparallel beta-sheet [[cite:PUB00093668],[cite:PUB00100986]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093668":{"PMID":31285597,"ISBN":null,"volume":"15","issue":"8","year":2019,"title":"A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan.","URL":null,"raw_pages":"803-812","medline_journal":"Nat Chem Biol","ISO_journal":"Nat. Chem. Biol.","authors":["Reisky L","Prechoux A","Zuhlke MK","Baumgen M","Robb CS","Gerlach N","Roret T","Stanetty C","Larocque R","Michel G","Song T","Markert S","Unfried F","Mihovilovic MD","Trautwein-Schult A","Becher D","Schweder T","Bornscheuer UT","Hehemann JH."],"DOI_URL":null},"PUB00100986":{"PMID":24816101,"ISBN":null,"volume":"70","issue":"Pt 5","year":2014,"title":"Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.","URL":null,"raw_pages":"1321-35","medline_journal":"Acta Crystallogr D Biol Crystallogr","ISO_journal":"Acta Crystallogr D Biol Crystallogr","authors":["Sidhu NS","Schreiber K","Propper K","Becker S","Uson I","Sheldrick GM","Gartner J","Kratzner R","Steinfeld R."],"DOI_URL":null}},"set_info":{"accession":"CL0088","name":"Alk_phosphatase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":46,"interactions":0,"matches":3396,"pathways":0,"proteins":3391,"proteomes":1958,"sets":1,"structural_models":{"alphafold":2414},"structures":11,"taxa":4533},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":1967},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}