{"metadata":{"accession":"PF16344","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR032508","hierarchy":null,"name":{"name":"FecR, C-terminal","short":"FecR_C"},"description":[{"text":"<p>This domain is found at the C-terminal of FecR [[cite:PUB00151597],[cite:PUB00016138]], which adopts a secretin N0-like fold [[cite:PUB00151597]]. FecARI are responsible for induction of the ferric citrate uptake system. When ferric citrate binds FecA, a signal is transmitted across the outer membrane to FecR, a cytoplasmic membrane protein that transmits signal across the membrane and activates the sigma-70 family protein FecI [[cite:PUB00016138]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151597":{"PMID":32107313,"ISBN":null,"volume":"295","issue":"17","year":2020,"title":"Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria.","URL":null,"raw_pages":"5795-5806","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Jensen JL","Jernberg BD","Sinha SC","Colbert CL."],"DOI_URL":null},"PUB00016138":{"PMID":10633096,"ISBN":null,"volume":"182","issue":"3","year":2000,"title":"Surface signaling in ferric citrate transport gene induction: interaction of the FecA, FecR, and FecI regulatory proteins.","URL":null,"raw_pages":"637-46","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Enz S","Mahren S","Stroeher UH","Braun V."],"DOI_URL":"http://dx.doi.org/10.1128/JB.182.3.637-646.2000"}},"set_info":{"accession":"CL0751","name":"Secretin_N0"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":36,"interactions":0,"matches":22286,"pathways":0,"proteins":22280,"proteomes":2482,"sets":1,"structural_models":{"alphafold":14798},"structures":2,"taxa":3570},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":305,"alignment:full":10738},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}