{"metadata":{"accession":"PF16289","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR032557","hierarchy":null,"name":{"name":"PIN domain","short":"PIN_12"},"description":[{"text":"<p>This domain is found on the N-terminal region of uncharacterized proteins. It shows homology to other PIN-like families and contains several acidic residues critical for chelating metal ions that are conserved in other PIN-like domains [[cite:PUB00091006]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"PIN_domain","extract":"<p>In molecular biology the <b>PIN domain</b> is a protein domain that is about 130 amino acids in length. PIN domains function as nuclease enzymes that cleave single stranded RNA in a sequence- or structure-dependent manner.</p>","thumbnail":null}],"literature":{"PUB00091006":{"PMID":28575517,"ISBN":null,"volume":"45","issue":"12","year":2017,"title":"Comprehensive classification of the PIN domain-like superfamily.","URL":null,"raw_pages":"6995-7020","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Matelska D","Steczkiewicz K","Ginalski K."],"DOI_URL":"https://doi.org/10.1093/nar/gkx494"}},"set_info":{"accession":"CL0280","name":"PIN"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":1106,"pathways":0,"proteins":1104,"proteomes":1020,"sets":1,"structural_models":{"alphafold":644},"structures":0,"taxa":2210},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":41,"alignment:full":500},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}