This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length. Several members are associated with vancomycin virulence in Staph. aureus in some way [[cite:PUB00076539]]. These proteins are all lipoproteins, carrying the characteristic prokaryotic membrane-attachment site at their N-termini.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00076539":{"PMID":22492855,"ISBN":null,"volume":"205","issue":"11","year":2012,"title":"Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus.","URL":null,"raw_pages":"1677-87","medline_journal":"J Infect Dis","ISO_journal":"J. Infect. Dis.","authors":["Cameron DR","Ward DV","Kostoulias X","Howden BP","Moellering RC Jr","Eliopoulos GM","Peleg AY."],"DOI_URL":"http://dx.doi.org/10.1093/infdis/jis252"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":6,"pathways":0,"proteins":6,"proteomes":5,"sets":0,"structural_models":{"alphafold":6},"structures":1,"taxa":17},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":1,"alignment:full":1},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4lqz","name":"Crystal structure of a DUF4909 family protein (SAV1798) from Staphylococcus aureus subsp. aureus Mu50 at 1.92 A resolution"}}}