Members of this family are often found in the gene neighbourhood, or fused to, non-ribosomal peptide synthetases.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00057486":{"PMID":20023723,"ISBN":null,"volume":"5","issue":"12","year":2009,"title":"Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins.","URL":null,"raw_pages":"1636-60","medline_journal":"Mol Biosyst","ISO_journal":"Mol Biosyst","authors":["Iyer LM","Abhiman S","Maxwell Burroughs A","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1039/b917682a"}},"set_info":{"accession":"CL0979","name":"DUF4872-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":2006,"pathways":0,"proteins":2006,"proteomes":1784,"sets":1,"structural_models":{"alphafold":1216},"structures":0,"taxa":2695},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":51,"alignment:full":859},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}