{"metadata":{"accession":"PF16090","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR032147","hierarchy":null,"name":{"name":"Protein capicua homolog-like domain","short":"Cic"},"description":[{"text":"<p>This domain is found in protein capicua homolog (Cic) and similar animal proteins. Cic is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, it is involved in brain development [[cite:PUB00148730],[cite:PUB00053281],[cite:PUB00148732]]. This domain is predicted to adopt a mainly beta-configuration.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00148732":{"PMID":28288114,"ISBN":null,"volume":"49","issue":"4","year":2017,"title":"Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.","URL":null,"raw_pages":"527-536","medline_journal":"Nat Genet","ISO_journal":"Nat Genet","authors":["Lu HC","Tan Q","Rousseaux MW","Wang W","Kim JY","Richman R","Wan YW","Yeh SY","Patel JM","Liu X","Lin T","Lee Y","Fryer JD","Han J","Chahrour M","Finnell RH","Lei Y","Zurita-Jimenez ME","Ahimaz P","Anyane-Yeboa K","Van Maldergem L","Lehalle D","Jean-Marcais N","Mosca-Boidron AL","Thevenon J","Cousin MA","Bro DE","Lanpher BC","Klee EW","Alexander N","Bainbridge MN","Orr HT","Sillitoe RV","Ljungberg MC","Liu Z","Schaaf CP","Zoghbi HY."],"DOI_URL":null},"PUB00148730":{"PMID":12393275,"ISBN":null,"volume":"106","issue":"1-2","year":2002,"title":"CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons.","URL":null,"raw_pages":"151-6","medline_journal":"Brain Res Mol Brain Res","ISO_journal":"Brain Res Mol Brain Res","authors":["Lee CJ","Chan WI","Cheung M","Cheng YC","Appleby VJ","Orme AT","Scotting PJ."],"DOI_URL":null},"PUB00053281":{"PMID":17190598,"ISBN":null,"volume":"127","issue":"7","year":2006,"title":"ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.","URL":null,"raw_pages":"1335-47","medline_journal":"Cell","ISO_journal":"Cell","authors":["Lam YC","Bowman AB","Jafar-Nejad P","Lim J","Richman R","Fryer JD","Hyun ED","Duvick LA","Orr HT","Botas J","Zoghbi HY."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2006.11.038"}},"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":28,"interactions":0,"matches":1549,"pathways":0,"proteins":1545,"proteomes":802,"sets":1,"structural_models":{"alphafold":277},"structures":0,"taxa":2815},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":199,"alignment:full":1065},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}