{"metadata":{"accession":"PF16062","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR032063","hierarchy":null,"name":{"name":"ADP-ribosylhydrolase MavL-like","short":"MavL-like"},"description":[{"text":"<p>This entry represents a class of MavL-like macrodomain enzymes whose representative members show unique selectivity for mono-ADP-ribosylated arginine residue in synthetic substrates, including [swissprot:Q9W2W5] and [swissprot:Q9W4J9] from Drosophila melanogaster, which are distantly related to MavL from Legionella pneumophila [[cite:PUB00155313]]. They are (ADP-ribosyl)hydrolases that share a mode of ADP-ribose interaction distinct from previously characterised macrodomains [[cite:PUB00155313]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155313":{"PMID":38503748,"ISBN":null,"volume":"15","issue":"1","year":2024,"title":"Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain.","URL":null,"raw_pages":"2452","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Zhang Z","Fu J","Rack JGM","Li C","Voorneveld J","Filippov DV","Ahel I","Luo ZQ","Das C."],"DOI_URL":"https://doi.org/10.1038/s41467-024-46649-2"}},"set_info":{"accession":"CL0861","name":"MavL-like_sf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":24,"interactions":0,"matches":750,"pathways":0,"proteins":581,"proteomes":319,"sets":1,"structural_models":{"alphafold":470},"structures":2,"taxa":1126},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":536},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8dmu","name":"Crystal structure of macrodomain CG3568 from Drosophila melanogaster in complex with ADP-ribose"}}}