{"metadata":{"accession":"PF16041","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR032010","hierarchy":null,"name":{"name":"E3 ubiquitin-protein ligase APD1-4, middle domain","short":"APD1-4_M"},"description":[{"text":"<p>This entry includes E3 ubiquitin-protein ligase APD1 to 4 from Arabidopsis. They are involved in pollen mitosis II (PMII) regulation during male gametogenesis [[cite:PUB00096500]]. This entry represents a functionally uncharacterised domain found in the middle of APD1-4 and in uncharacterised sequences mainly from arthropods. There are two completely conserved C residues that may be functionally important.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00096500":{"PMID":22897245,"ISBN":null,"volume":"54","issue":"10","year":2012,"title":"Four closely-related RING-type E3 ligases, APD1-4, are involved in pollen mitosis II regulation in Arabidopsis.","URL":null,"raw_pages":"814-27","medline_journal":"J Integr Plant Biol","ISO_journal":"J Integr Plant Biol","authors":["Luo G","Gu H","Liu J","Qu LJ."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":56,"interactions":0,"matches":1862,"pathways":0,"proteins":1852,"proteomes":646,"sets":0,"structural_models":{"alphafold":1465},"structures":0,"taxa":2179},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":31,"alignment:full":1142},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}